Stem cells: from biomedical research towards clinical applications

Hematopoietic and Mesenchymal Stem Cells in Biomedical and Clinical Applications

1 Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia 2Division of Experimental Cancer Research, Department of Laboratory Medicine, Lund University, Malmö, Sweden 3Department of Genetics and Bioengineering, T.C. Yeditepe Üniversitesi, Istanbul, Turkey 4Excellence Cluster Cardio-Pulmonary System, Justus Liebig University, Giessen, Germany 5CNC-Center for Neuros...

Engineering Stem Cells for Biomedical Applications.

Stem cells are characterized by a number of useful properties, including their ability to migrate, differentiate, and secrete a variety of therapeutic molecules such as immunomodulatory factors. As such, numerous pre-clinical and clinical studies have utilized stem cell-based therapies and demonstrated their tremendous potential for the treatment of various human diseases and disorders. Recentl...

iPS Cells: Born-Again Stem Cells for Biomedical Applications

Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in Cancer

The human induced pluripotent stem cells (hiPSCs) are derived from a direct reprogramming of human somatic cells to a pluripotent stage through ectopic expression of specific transcription factors. These cells have two important properties, which are the self-renewal capacity and the ability to differentiate into any cell type of the human body. So, the discovery of hiPSCs opens new opportuniti...

Induced pluripotent stem cells (iPSCs) in the gastroenterology and hepatology: from basic research to clinical applications.

Aims & Scope: The discovery of induced pluripotent stem cells (iPSCs) and mature cell reprogramming, for which John Gurdon and Shinya Yamanaka were jointly awarded 2012 Nobel Prize in Physiology and Medicine, has opened a novel potential avenue for developing more specific and potent approaches to combat various gastrointestinal and liver diseases including cancers. Cellular reprogramming is a ...